Emerson Exchange 365

Activity

Improving Product and Process Development in Life Sciences

Jim Cahill

“Driving the Future of Pharma” is the theme for next week’s fully digital 2020 ISPE Annual Meeting and Expo . The focus for the meeting is: …on steering the future of pharmaceutical science and manufacturing toward a more global, synchronized, and quality-driven industry. Emerson’s Michalle Adkins will be discussing villains and heroes in knowledge management . Michalle’s poster presentation addresses the question…
- 30 Oct 2020
Simplifying Pneumatic Valve Installations

Jim Cahill

Biopharmaceutical manufacturers seek ways to more quickly and efficiently scale up their operations as well as maintain quality control processes when bringing new products to market. Automation is one place to help drive these improvements. Emerson’s Mukta Sharma alerted me to a whitepaper, How to Simplify Your Pneumatic Valve Installation to Improve Your Drug Manufacturing Operation , which highlights the critical…
- 16 Oct 2020
Emerson technologies helping world meet urgent need for ventilators

Jim Cahill

Even before the critical global demand caused by the coronavirus pandemic, the twin challenges of a worldwide aging population and associated lung disease had led to an increased need for ventilators. However, the Covid-19 crisis has heightened the urgent demand for ventilators to extraordinary levels, putting intense pressure on the production capabilities of medical equipment manufacturers. The simple purpose of…
- 23 Sep 2020
Building Digital Transformation, One Step at a Time

Jim Cahill

In a Flow Control magazine article, Seven Digital Transformation Myths Exposed, Emerson’s Brian Joe offers advice on starting a digital transformation program. When we talk to companies about digital transformation, especially companies that have yet to launch a program, we frequently hear two kinds of responses representing two extremes. Either they don’t think the technologies work, or they have inflated expectations…
- 31 Aug 2020
Accelerate Technology Transfer through the Product Development Pipeline

Jim Cahill

In this age of rapid races for vaccines and therapeutics to battle the Coronavirus, there is even greater focus on the technology transfer process through the product development pipeline to commercial production. Emerson’s Michalle Adkins and Ron Rossbach will host a webinar on reducing time to market for a new therapies—a key opportunity for pharmaceutical and biopharmaceutical manufacturers. This webinar will take…
- 11 Aug 2020
Choosing Temperature Instrumentation Should Begin with Understanding the Process

Jim Cahill

In a Process Heating magazine article titled Questions to Ask About Temperature Measurement Applications , Emerson’s Sarah Kendrick helps engineers work through the critical temperature application design process. Imagine this: One of your process engineers comes to you, points to a P&ID and says, “We need a new process temperature measurement right here. Take care of it.” What is the first thing you need to know to ensure…
- 8 Aug 2020
Optimizing Biopharmaceutical Manufacturing Processes

Jim Cahill

Optimizing both continuous and batch-based processes have their unique challenges. I caught up with Emerson’s Alan Johnston who shared with me how technology advances in real-time modeling, adaptive scheduling and predictive maintenance are enabling successes in optimization for biopharmaceutical manufacturers who may have a combination of both types of processes in their operations. The performance objectives are typically…
- 14 Jul 2020
Life Sciences Operational Performance Improvement Webinar Series

Jim Cahill

With events across our industry still on Coronavirus hiatus, we’re fully into webinar season as a replacement. For pharmaceutical and biopharmaceutical manufacturers, we have a Life Sciences.NOW webinar series . This series includes eight interactive discussions on digital plant technologies and will provide direction and updates on key manufacturing operation initiatives to improve operational performance, deliver…
- 16 Jun 2020
BioPhorum Collaboration for Improving Biopharmaceutical Manufacturing

Jim Cahill

Let’s recognize the tremendous efforts by people in the Life Sciences industry racing for solutions to COVID-19 Coronavirus treatments and vaccines. In an unprecedented way, many are scaling up for full production while still in the early phases of development. We’re all hoping that one or several treatments will work in helping wind down this challenging era. Over the years, pharmaceutical and biopharmaceutical manufacturers…
- 22 May 2020
Oral Solid Drug Continuous Manufacturing

Jim Cahill

With the global focus around the COVID-19 Coronavirus pandemic, manufacturers in the pharmaceutical and biotech industries have been racing to find both treatments and preventive vaccines. Batch processing has been the historical method of production for these Life Science companies. Continuous processing, which holds the promise of greater development and production flexibility, has continued to become a reality. …
- 6 May 2020
BioPhorum Best Practices on Knowledge Management

Jim Cahill

Michalle Adkins The BioPhorum organization was formed in 2004 with the mission, “…to create environments where the global biopharmaceutical industry can collaborate and accelerate its rate of progress, for the benefit of all.” Emerson’s Michalle Adkins alerted me to the release of a new BioPhorum Knowledge Management white paper, A Test Case in CMC Business Processes from Late-Stage Development to Commercial Manufacturing…
- 30 Mar 2020
Improving CAR-T Therapeutical Production

Jim Cahill

Alan Johnston With the world’s attention focused on the Coronavirus, I wanted to focus on some of the amazing therapies being developed in the Life Sciences industry. I caught up with Emerson’s Alan Johnston who shared a presentation he gave at the Simposio AFI last year. He discussed gene therapy, cell therapy and CAR-T which combines both. These have the goal to treat disease by changing the blueprint to our body…
- 26 Mar 2020
Accelerating the Development and Production of Therapeutics

Jim Cahill

The focus of the world right now is on how to defeat the Coronavirus and return to more normal times. Manufacturers in the Life Sciences industry are racing at a breakneck pace to develop vaccines and treatments. Automation, analytics play a large role in both the development process for new therapies and ongoing optimized production. I’ve shared many of the ways how in blog posts in the Life Sciences & Medical category…
- 20 Mar 2020
Biopharmaceutical Models in Development and Production

Jim Cahill

Bob Lenich Models of manufacturing and production processes can provide value through the lifecycle of these facilities, from up front design through ongoing personnel training and optimization. One quick example is the simulation used to test out the control strategies before commissioning the control system. In a BioPharm International article, Biopharma modeling, now and five years from now , Emerson’s Bob Lenich…
- 11 Mar 2020
Real-Time Adaptive Scheduling in Life Science Manufacturing

Jim Cahill

Pharmaceutical & Biopharmaceutical manufacturers face the continued challenge of how to achieve maximum capacity in their facilities. Often a facility does not achieve maximum design capacity due to hidden operational bottlenecks. One way to drive performance gains is to identify the causes behind this situation and operate as close to design specifications as is possible. At the Biomanufacturing World Summit, Emerson…
- 10 Mar 2020
Biopharmaceutical Product and Process Knowledge Management

Jim Cahill

The American Productivity & Quality Center (APQC) , a world-leading authority in knowledge management (KM), defines KM: The application of a structured process to help information and knowledge flow to the right people at the right time so they can act more efficiently and effectively to find, understand, share, and use knowledge to create value. For biopharmaceutical producers, creating value from the knowledge capture…
- 12 Feb 2020
Sharing Best Practices on Path to Pharma 4.0

Jim Cahill

Pharma 4.0 is an initiative based on Industry 4.0, begun out of the International Society for Pharmaceutical Engineering Germany/Austria/Switzerland (ISPE D/A/CH) organization, which lead to the formation of : …the ISPE Pharma 4.0 special interest group (SIG) in 2017. Pharma 4.0 envisions highly efficient automated processes—which could be continuous, batch, or a hybrid of these—driven by an integrated manufacturing…
- 27 Jan 2020
Predictive and Prescriptive Maintenance in Life Sciences

Jim Cahill

When you think of machinery for industrial use, often images of refineries, oil & gas production sites and other visual images come to mind. But what about the machinery and other equipment in industries with shiny stainless steel everywhere, such as pharmaceutical, biotech and food & beverage manufacturing? Dennis Belanger The pumps, fans, and other pieces of process equipment must operate reliably and be part of…
- 17 Jan 2020
Innovating to Meet Bioprocessing Single-Use Requirements

Jim Cahill

Manufacturing in the biotech industry has been undergoing many changes. An ADC Review article, Emerging Trends in Single-Use Technology in the Manufacturing of Antibody-Drug Conjugates , highlighted one of these trends: First introduced in the late 1970s in the form of disposable capsules and a range of filters, single-use technologies were revolutionized in the late 2000s with the introduction of single-use 2D and…
- 25 Oct 2019
Biomanufacturing Fluidic System Single-Use Technologies

Jim Cahill

Mukta Sharma As medicines and therapies become more specialized for individuals, the requirements of biopharmaceutical manufacturing processes are dramatically changing, especially in the transition from large-scale to single-use production processes. In a Processing magazine article, Process Control Automation Systems Maximize Biomanufacturing Agility in Single-Use Applications , Emerson’s Mukta Sharma highlights…
- 9 Oct 2019
Sensors for Single-Use Bioreactors

Jim Cahill

Michael Francis For pharmaceutical and biopharmaceutical manufacturers, scaling up production has typically meant large, 5000+ liter stainless steel bioreactors for the process. These require cleaning and sterilization between batches. Market demands are driving the need for more flexibility with smaller batches. Single-use technologies (SUT) are being applied to bioreactors to address these demands and reduce the cost…
- 22 Aug 2019
Optimizing Biomanufacturing in Real Time

Jim Cahill

One of the inherent challenges in top-down scheduling systems, such as manufacturing plans generated from Enterprise Resource Planning (ERP) systems (Level 4 in ANSI/ISA-95 model ), are that they are typically based on the ideal state of manufacturers’ processes. The real state may quite different and include issues with equipment, processing steps that didn’t go as planned, and other less-than-ideal occurrences. For…
- 24 Apr 2019
Taming Big Data in the Life Sciences

Jim Cahill

Bob Lenich The Interphex conference for pharmaceutical and biotech manufacturers is underway this week in New York City. Emerson’s Bob Lenich is presenting Big Data in Life Sciences Manufacturing. Bob opens citing one pharmaceutical manufacturer who generates 5000 data points every second during a production run. This data rate translates into 1.3*10 10 pieces of data per production run. Here are some of the data…
- 3 Apr 2019
BioPhorum Roadmap for In-line Monitoring and Real-time Release

Jim Cahill

Professionals across the Life Sciences industry are gathering this week in New York City for Interphex . Organizers bill this conference as: …the premier pharmaceutical, biotechnology, and device development and manufacturing event where you can “Experience Science through Commercialization”. Michalle Adkins Emerson’s Michalle Adkins will be presenting, Update on BioPhorum’s Roadmap for In-line Monitoring and Real…
- 1 Apr 2019
Advancing Digital Plant Maturity for Biopharmaceutical Manufacturers

Jim Cahill

Ron Rossbach At the recent 2019 China International Biopharma4.0 Summit , Emerson’s Ron Rossbach presented Biopharma 4.0—Integrated Software Enabling Digital Capabilities. I’ll highlight some of Ron’s key points. He opened describing some of the main challenges biopharmaceutical manufacturers seek to address through enterprise digitalization—reducing time to market, increasing capital expenditure (CAPEX) productivity…
- 28 Mar 2019